Spaghetti and meatballs is an Italian-American pasta dish consisting of spaghetti, tomato sauce, and meatballs.

Originally inspired by similar dishes from southern Italy, the modern version of spaghetti and meatballs was developed by Italian immigrants in the United States. However, combinations of pasta with meat date back at least to the Middle Ages, and pasta (including long pasta) dishes with tomato sauce and different types of meatballs are documented in certain Italian regions and in modern Italian cookbooks as maccheroni alle polpette (translated as 'spaghetti and meatballs') and maccheroni alla chitarra con polpette, although these dishes are often found only in particular regions and towns.